Common medication cuts free sales colorecate cancer in half
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A common free sale medication could significantly reduce the risk of colorectal cancer returning.
In a Swedish study, it was shown that a low dose of aspirin reduces recurrence by half for patients with colon and rectal cancer whose tumors had a specific type of genetic mutation.
Researchers at the Hospital of the University of Karolinska and the Karolinska University Hospital followed more than 3,500 patients with 33 hospitals cancer in Sweden, Norway, Denmark and Finland, according to a press release. All patients underwent surgery to remove their tumors.
At the long distance that was tied to a higher risk of colon cancer, it suggests an early study
Among those who had a particular genetic mutation in the Pik3 signaling route, half of them received 160 milligrams of aspirin daily and the other half received a placebo.
After a period of three years, the risk of cancer recurrence was reduced by 55% in those who took aspirin compared to the placebo group.
A common free sale medication could significantly reduce the risk of colorectal cancer returning. (Istock)
“The Aascca essay shows for the first time in a random environment that the low dose aspirin significantly reduces recurrence in patients with colorectal cancer with alterations of the PI3K somatic pathway,” the author of the Anna Martling, MD, PH.D., professor of the Department of Medicine and Molecular Surgery, Karolinska Instituta and Senior Consultant of the Surfo of the Surfo of the South of the University of News.
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“This applies to more than a third of all patients with resected colorectal cancer.”
The effect was stronger in women, which guarantees greater research, according to Martling.
The findings were published in the New England Journal of Medicine.
“The tests of via PI3K alterations should be considered in patients with colorectal cancer after surgery.”
Aspirin is a medicine that is available worldwide and extremely economic compared to many modern cancer medications, Martling said.
Destined to relieve pain, fever and inflammation, aspirin is a non -steroidal anti -inflammatory drug (NSAIDs). The low doses of medication are also used to prevent blood clots.
This research confirms what has suggested previous observation studies, this time in a randomized study.
It was shown that a low aspirin dose reduces recurrence in half for patients with colon and rectal cancer whose tumors had a specific type of genetic mutation. (Istock)
Dr. Marc Siegel, a senior medical analyst at News, did not participate in the study, but shared his reaction in an interview with News Digital.
“Aspirin is anti -inflammatory and is involved with the mitigation of growth factors,” he said. “Numerous studies have shown that regular NSAID use has decreased the risk of developing and dying from colon cancer.”
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The Pik3ca mutation in the study leads to rapid cell growth in cancers, which is in 55% of breast cancers and approximately 30% of colon cancers, Siegel said.
“This great random Scandinavian study reveals a recurrence reduction of more than 50% in those with colon cancer and the Pik3 mutation,” he reiterated, adding that more research should be done.
After a period of three years, the risk of cancer recurrence was reduced by 55% in those who took aspirin compared to the placebo group. (Istock)
The study had some limitations, the author acknowledged. “As with any essay, there are warnings. The study was not driven for detailed subgroup analysis, and patients over 80 were not included,” Martling said.
“Longer follow -up is also needed to confirm the effects on general survival.”
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According to researchers, some common side effects of aspirin include stomach problems and a greater trend of bleeding. It should not be used by people with stomach ulcers, hemorrhagic disorders or asthma.
Aspirin is a medicine that is available worldwide and extremely economic compared to many modern cancer medications, the researcher said. (Photo AP/Patrick Sison, Archive)
Those who use other blood grain or alcohol agents should use aspirin with caution, experts advise.
Despite the limitations, researchers believe that the results are “immediately relevant” for doctors and guidelines.
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“The tests of via PI3K alterations should be considered in patients with colorectal cancer after surgery,” Martling recommended. “However, for patients, it is important to know that aspirin is not recommended outside a medical context until the guidelines and treatment of doctors adopt these findings.”
“If it is implemented widely, the regime could avoid thousands of recurrences and save lives every year.”
The trial is a strong example of “precision medicine”, according to the researcher, and high -tech platforms that meet a well -known and low -cost medicine.
“If it is widely implemented, the regime could avoid thousands of recurrences and save lives every year, especially in environments where access to new and expensive drugs is limited,” he added.
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When asked if everyone who has experienced colon cancer should receive regular aspirin, Siegel said that it should be used more commonly for this, but that doctors need to analyze the risks and benefits of aspirin use case by case.
The study was financed by the Swedish Research Council and the Swedish Cancer Society.
Melissa Rudy is a senior health editor and a member of the lifestyle in News Digital. The advice of history can be sent to melissa.rudy@News.com.