Exercise can prevent cognitive deterioration even when energy is delayed, researchers discover

Even in the days you stay with energy, exercise can boost your brain.

According to researchers from the University of Missouri (Mizzou), who made a specific discovery on the brain benefits of physical activity.

The study, published in the Physiology magazine, examined what happens with the brains of people who have limited ketones in the liver.

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When the body has little glucose, its usual fuel, the liver produces ketones, which help generate energy and feed the brain, according to the press release of the study.

These molecules support cognitive memory, learning and health of the general brain.

Even when the liver cannot produce enough ketones, the exercise helps to compensate for this loss, discovered that potentially reverses some cognitive impairment.

This is especially frequent as people age and face a greater risk of conditions such as Alzheimer’s disease.

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These findings are also promising for those who have liver conditions that prevent the body from producing ketones.

The main investigator of the R. Scott Rector study, Ph.D., professor at the Faculty of Medicine and Director of the Precision Health Building, he commented on the study in an interview with News Digital, noting that the natural production of ketones of the body is important to maintain the healthy brain.

“It helps maintain memory, learning skills and health factories in the brain (mitochondria),” he said.

“Exercise can still protect the brain even when the liver is not making ketones, which could be relevant to people with liver disease, which causes a reduced production of ketones.”

These findings were surprising for researchers, according to rector, who expected the exercise could not improve the health of the brain when Cetona production was limited.

“Exercise can still protect the brain even when the liver is not making ketones.”

“However, it seems that exercise has backup pathways that improve brain health, even when Cetona production is compromised,” he said.

Another principal investigator, Taylor Kelty, a postdoctoral fellow in the rector’s laboratory, said that previous investigations have begun to show the link between severe liver dysfunction and a high risk of dementia.

“If Cetona production in the liver is interrupted, it could be a possible cause of cognitive impairment, which leads to conditions as dementia,” Kelty said in the press release.

These findings reinforce the role of the exercise in keeping people “mentally acute”, in addition to being a “key piece of puzzle to preserve brain health as we age,” according to the researcher.

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Rector pointed out that the active exercise “many other roads” in the liver that could also help the brain, although that was not a focus of this study.

“In the future, we need to study these other molecules and backup systems that still drive brain health,” he told News Digital.

“The health’s health benefits are particularly important for those who have liver conditions such as MASLD (steathic liver disease associated with metabolic dysfunction),” he added.

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“Scientists are increasingly evidenced that liver health affects brain diseases such as Alzheimer’s disease,” he said.

“Scientists are increasingly evidenced that liver health affects brain diseases such as Alzheimer’s disease.”

“Our findings suggest that taking care of the liver and understanding the metabolism of ketones could be a new way of helping to prevent or slow down brain diseases.”

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The research was funded by the National Health Institutes as part of NIH’s molecular transducers of the physical activity consortium.