Bidens prostate cancer is that hormones sensitive doctors break down what that means

The recent diagnosis of Joe Biden of “aggressive” prostate cancer has caused concerns about what extent the disease has advanced.

The former president’s prostate cancer has been characterized by a Gleason score of 9 (grade group 5) with “metastasis to the bone.”

The 9 score indicates “high -grade” prostate cancer with very abnormal cells that will probably grow rapidly, experts say.

Biden prostate cancer described as “aggressive”: what to know about the prognosis of the disease

“While this represents a more aggressive form of the disease, cancer seems to be sensitive to hormones, allowing effective management,” said the statement. “The president and his family are reviewing the treatment options with their doctors.”

The fact that Biden cancer has been classified as “sensitive to hormones” means that it could respond more to hormonal therapies and, therefore, more treatable.

Hormone -sensitive prostate cancer needs androgens (male hormones), according to the National Cancer Institute. When those androgens are reduced or block, cancer stops growing.

Dr. Marc Siegel, Clinical Professor of Medicine at Nyu Langone Health and Senior Medical Analyst of News, said that hormones sensitive designation does not necessarily mean that Biden has already been taking hormonal therapies, which is unknown.

Gleason score for prostate cancer: What to know about the diagnosis of Biden

“You can say under a microscope if this is the type of cancer that could respond to hormonal therapy, but it doesn’t matter how it looks, you don’t know until you try it,” he told News Digital.

“And sometimes it seems that there will be an effect, but it ends up being resistant to therapy.”

For a long time it is known that prostate cancer feeds on testosterone male hormone, according to Dr. Bilal Siddiqui, MD, a medical oncologist and researcher of prostate cancer at the MD Anderson Cancer Center of the University of Texas.

“The overwhelming majority of prostate cancers, 99% more, are sensitive to hormones and depend on testosterone at the beginning,” Digital News told News.

“I would say it is a very reasonable assumption [of hormone sensitivity]but we would definitely know once the hormonal therapy has begun. “

“The overwhelming majority of prostate cancers are sensitive to hormones and depend on testosterone at the beginning.”

The spine of treatment for any metastatic prostate cancer is the “androgen deprivation therapy”, which is oriented to the decrease in the body’s testosterone level.

“Usually, when androgen deprivation therapy begins, testosterone levels will decrease and PSA levels will decrease along with it, and that is its definitive proof that cancer is sensitive to hormones,” said Siddiqui.

Historically, androgen deprivation therapy (hormone) was surgically performed by eliminating the testicles, but today’s typical methods include pills or injections, according to the oncologist.

“That eliminates between 80 and 85% of the testosterone produced in the body,” he said.

In many cases, doctors can add other medications to block testosterone from secondary sources in the body, such as adrenal glands that are above the kidneys.

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North Carolina family doctor, Dr. Alexa Mieses Malchuk, reiterated that prostate cancer shrinks or slows down the progression after blocking testosterone qualifies as sensitive hormones.

“This means that it grows or shrinks in relation to the amount of androgen or testosterone circulating in the body,” he told News Digital.

“If you suppress testosterone and cancer it is not reduced and continues to grow or spread, then cancer is independent of the amount of hormone circulating in the body.”

There are several different ways to monitor the progression of the disease, but it is done more frequently due to a combination of PSA blood and image studies, the doctor said.

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Finally, metastatic prostate cancer will progress to become hormone resistant, which means that it no longer responds to hormonal therapy, according to Siddiqui.

“It can vary in how long it takes to reach that point,” said the oncologist. “Usually, they spent a couple of years before evolving hormones sensitive to hormone resistant.”

The “final test” of whether cancer has become hormones resistant is to reduce testosterone levels and observe where cancer is going, he said.

“Usually, they spent a couple of years before evolving hormones sensitive to hormone resistant.”

There may also be signs that the disease worsens.

“That could mean a growing PSA test (specific prostate antigen), new pain or symptoms, or new tumors that appear in exploration,” Siddiqui told News Digital.

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The US Preventive Services Task Force. UU. It states that men aged 55 to 69 must have the option of undergoing periodic detection based on prostate antigen (PSA) to monitor prostate cancer.

“Before deciding whether to be evaluated, men should have the opportunity to discuss the possible benefits and damage of detection with their clinician and incorporate their values ​​and preferences in the decision,” says the USPSTF.

Siegel questioned this guide to omit the detection of older men.

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“I do not agree with the guidelines not to try more than 70 years, especially with so many treatments to offer for prostate cancer,” he said.

In addition to hormonal therapy, some men can be candidates for robotic prostate, chemotherapy and radiation surgery, Siegel added.