Cold sores can play a role in Alzheimer’s development, reveals new research

Cold sores can play a role in the development of Alzheimer’s disease, according to a new study published in BMJ Open.

The researchers examined 344,628 “cases of cases and controls.” Couples combined in age, sex, geographical region and number of health visits, but one had Alzheimer’s disease and did not.

Of the groups studied, 1,507 people with Alzheimer also had the Simple Herpes virus type 1 (HSV-1), which is the most common cause of cold sores. Only 823 people in the control group had HSV-1.

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Among these 2,330 people, 40% used anti-child medication after diagnosis.

Those who were treated by the virus had 17% less likely to develop Alzheimer’s disease than those who did not use the treatments, according to the study.

It is known that the risk of developing this form of dementia increases with age. However, the possibility of a diagnosis of HSV-1 was 80% higher in those diagnosed with Alzheimer’s, according to the investigation.

Less frequently, cold sores can be caused by herpes simple type 2 herpes virus (HSV-2).

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The analysis puts “an even greater emphasis on the view of the prevention of herpes viruses as a public health priority,” researchers said in a press release.

In general, women constituted 65% of Alzheimer’s cases. Its average age was 73 years, and tended to have more coexisting conditions, which were risk factors.

The study also observed the potential role of other herpes viruses, some of which were associated with a high risk of Alzheimer’s disease.

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The specific connection between viruses such as HSV-1 and the greatest risk of dementia is not clear, the researchers pointed out.

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“However, studies have shown that inflammatory alterations in the brain caused by HSV infection are fundamental in [Alzheimer’s disease] Development, “they said in the statement.

Treatment with antiviral therapy seems to reduce Alzheimer’s risk “, suggesting that HSV-1 treatment can be protector,” says the study.

“There is no cure for cold sores, but the treatment can help control the shoots,” according to Mayo Clinic.

“Medicine or prescription antiviral creams can help sores to heal more quickly. And they can make future outbreaks less frequently and be shorter and less serious.”

Potential limitations

There were some limitations in the study, the researchers recognized.

“Due to the limited data history, HSV-1 infections before the patient database entry were not included in the analysis, and it is possible that there is a certain overlap between the HSV-1 and HSV-2 diagnoses,” said the researchers.

“In addition, many people with HSV-1 infection are asymptomatic, and others may not look for medical attention during recurrences and, therefore, are not diagnosed and recorded clinically in the database.”

Although it is estimated that two thirds of people under 50 are infected with HSV-1, data on symptomatic infections are limited, “since manifestations can be mild or unnoticed,” the researchers added.

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A sub-diagnosis diagnosis of Alzheimer’s disease could also bias the results.

News Digital communicated with researchers and other doctors to comment.