Scientists may have discovered why pounds come back after losing weight
Many factors lead to the frustrating cycle of weight gain and weight loss, but the driving force can be fat cells maintaining a Obesity Memory.
That is according to a recent study that was first published in the journal Nature the past fall.
Researchers say that fatty cells influence abnormal metabolic pathways in the body long after pounds are spill, which could make people more likely recover the weight.
The study directly compares Zepbound and Wogovy to obtain weight loss results
Study findings
The team of Swiss scientists was curious if Recover weight After losing weight it is due to the “metabolic memory”, where the body remembers and strives to return to its ancient state of obesity.
Many factors lead to the frustrating cycle of weight gain and weight loss, but the driving force may be that fatty cells maintain a memory of obesity. (Istock)
They analyzed chemical markers in fat cells in mice that were fed with a high fat diet. Then, when the mice were fed only with a standard meal, the researchers analyzed their fatty tissue after having lost weight, according to the study article.
Then, the team compared these samples with a group of lean mice that fed with a standard meal to see if chemical markers in fatty cells were associated with unhealthy changes in the body.
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The high -fat diet mice continued to have unhealthy changes in their metabolism after losing weight, including more difficulty to regulate sugar metabolism, more inflammation and abnormal storage of fats.
The mice that were previously obese increased faster weight compared to the control group after having eaten a high fat diet, which suggests continuous deterioration in metabolism after losing weight, the researchers found.
The mice that were previously obese increased faster weight compared to the control group after having eaten a high fat diet, which suggests continuous deterioration in metabolism after losing weight. (Istock)
The study also analyzed human samples, analyzing how genes in fatty cells can lead to unhealthy changes in the body as they did in mice.
The researchers analyzed the fatty tissues of the participants before and after they underwent bariatric surgery, comparing them with the fatty cells of individuals read that they had no history of obesity.
“This recent research suggests that after someone loses weight, their fat cells do not return to ‘normal’.”
In obese individuals, fatty cell genes continued to function abnormally in the body, which led to more inflammation and metabolic problems two years after losing weight.
A limitation of the study is that it only analyzed one type of cell cells: fat cells. More research is needed to determine if other cells or tissues in the body also maintain the memory of being overweight, the researchers recognized.
‘Complex mix’ of factors
Fat cells have the memory of being obese, which can facilitate weight recovery and remain in a state that promotes inflammation and metabolic problems, confirmed Gretchen Zimmermann, registered dietitian and vice president of clinical strategy in Health, a supplier of virtual obesity care. (She was not part of the study).
“This recent research suggests that after someone loses weight, their fat cells do not return to ‘normal,” Zimmermann told News Digital.
The researchers analyzed the fatty tissues of the participants before and after they underwent bariatric surgery, comparing them with the fatty cells of individuals read that they had no history of obesity. (Istock)
But although biology plays a fundamental role in obesity, it is not everything, he warned.
“A complex combination of genetics, biology, environment, psychology, medications and social determinants that shape obesity, “said Zimmermann.
“Keep moving, eating real food and building muscle.”
Healthy habits can counteract genetics that promote weight gain.
Ideally, said the expert, this implies obtaining a combination of physical activity (including strength training), a sufficient amount of protein and fiber, and phytonutrients of plants that counteract oxidative stress and chronic inflammation, according to Zimmermann.
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“Keep moving, eating real food and building muscle,” he said.
“These behaviors reduce inflammation, improve blood sugar control, contribute to a healthy microbiome and protect metabolism, even if the weight does not fall much or remains the same.”
Researchers say that healthy habits can counteract genetics that promote weight gain. (Istock)
For some, however, the underlying problem may be in Epigeneticswhich implies how the behaviors of a person and the surrounding environment influence how genes work in the body, according to the centers for disease control and prevention.
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“Obesity is a chronic relapse condition that has an epigenetic cause,” said Dr. Caroline Apovian, Medicine Professor at the Harvard School of Medicine and co -director of the Center for the Management of Weights and the well -being of the Women and Women’s Hospital, to News Digital.
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People who are more likely to store calories can have more difficulties in losing weight and maintaining it through diet and exercise, compared to those who may have an easier time, according to support, which did not participate in the study.
News Digital contacted the study authors to comment.