The new stem cell therapy shows ‘promising’ results to treat hair loss in preclinical trials

The new stem cell therapy shows ‘promising’ results to treat hair loss in preclinical trials

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Researchers at the San Carlos Clinical Hospital in Madrid have been aimed at a possible solution for hair loss.

A recent study analyzed the effect of injecting the skin of mice with stem cells of human fat (“stem cells derived from fattening (ASC)”, as a means to treat androgenetic alopecia (AGA), more commonly known as hair loss of the male or female pattern.

The team discovered that the male mice achieved the best hair growth after three weeks when they received ASC in low doses, combined with an energy reinforcement molecule called adenosine trifosphate (ATP).

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Treatments with low doses and high doses together with ATP led to an improvement in hair recovery in females, but median ASC in more ATP doses led to greater regeneration.

The researchers concluded that the return of the hair improved in “all experimental groups” where male mice received stem cell solutions complemented with ATP.

Man loss of man

Researchers at the San Carlos Clinical Hospital in Madrid have been aimed at a possible solution for hair loss. (Istock)

The findings were published in Stem Cell Research & Therapy.

The main author of the study Dr. Eduardo López Bran, dermatologist and professor at the Complutense University of Madrid, shared his expectations for the study in an interview with News Digital.

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“We expected good results, but not such a high level of success,” he said. “We are talking about a great degree of hair regrowth in male and female mice.”

With the appropriate doses, the researchers achieved “very high percentages” of hair regeneration, pointing out that 100% of male mice and up to 90% of female mice registered hair.

Laboratory mice in hand

With the appropriate doses, the researchers achieved “very high percentages” of hair regeneration, pointing out that 100% of male mice and up to 90% of female mice registered hair. (Real studio mice not in the photo). (Istock)

“These results show that advanced therapies can represent a new therapeutic approach for many diseases for which there are no effective treatments currently available,” Bran continued.

“Achieving such promising results in the preclinical phase with a completely novel approach to androgenetic alopecia, one that avoids chronic treatment and is also safe, is a significant scientific milestone.”

“We are talking about a great degree of hair regrowth in male and female mice.”

The main limitation of the study was the thinness of the mouse skin, said Bran, who “raised a challenge in the administration of therapy.”

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“This required the development of protocols to minimize experimental variability, and will be a key factor when humans begin,” he said.

Woman losing her hair in her hair

“Research advances point to possible solutions that, in the future, can offer lasting results without the need for continuous treatment to maintain benefits.” (Istock)

These new findings must be “interpreted with caution and scientific rigor,” Bran warned.

“Although the results in mice represent significant progress, it is also true that it is essential to wait for clinical benefits in humans.”

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The researcher encouraged those with androgenetic alopecia to continue consulting with their dermatologists and to follow the prescribed treatments as the investigation takes place.

“It is important to maintain hope. Research advances point to possible solutions that, in the future, can offer lasting results without the need for continuous treatment to maintain benefits,” added Bran.

“This study is small and more research is needed on this method as a potential treatment option.”

Looking forward to clinical trials in humans, researchers are “actively working” in confirmation of security for men and women between 18 and 50 years with moderate androgenetic alopecia, said the researcher.

“If everything progresses as expected, the most optimistic timeline indicates that the treatment is available in approximately five years,” he said.

Man combing hair in a bath at home

Looking forward to clinical trials in humans, researchers are actively working “in confirmation of security for men and women between 18 and 50 years with moderate androgenetic alopecia. (Istock)

In a separate interview with News Digital, Dr. Brendan Camp, MD, a New York headquarters who did not participate in the study, commented on the potential of this method.

“While it is not commercially available, this study suggests that the injection of stem cells supplemented with ATP into the skin of the scalp could encourage hair growth in individuals with androgenetic alopecia,” he reiterated.

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“This study is small and more research on this method is needed as a potential treatment option for androgenetic alopecia.”

Until then, Camp encourages people to focus on currently available and “well studied” treatments to address hair loss and visit a dermatologist certified by the Board for evaluation.

Angelica Stabile is a lifestyle reporter for News Digital.

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