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As cases of drug -induced liver lesion (Dili) are increasing, experts warn about hidden hazards associated with some drugs and common supplements.
Statistics show that Dili, also known as toxic hepatitis or hepatotoxicity, which is known to be a significant cause of acute liver failure, has been growing in Western countries since the 1960s.
Around a fifth of the total population that is prescribed medications will experience Dili, according to recent investigations published in the magazine toxicology reports.
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Possible triggers of liver lesion include herbal products, dietary supplements and medications, according to the study.
Those with pre -existing liver conditions and nutritional deficiencies have a higher risk, as are pregnant women.
As cases of drug -induced liver lesion are increasing, experts warn about hidden dangers associated with some common medications and supplements. (Istock)
How drugs can damage the liver
One of the main functions of the liver is to break the substances taken orally, including supplements and medications, according to the American College of Gastroenterology (ACG).
For some people, the process of metabolization of these substances can be slower, increasing the risk of liver damage.
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Even medications that have been tested for safety and approved by the Food and Medicines Administration of the United States (FDA) can cause liver lesions in rare cases, said the ACG.
Common symptoms of liver disease include nausea, loss of appetite, abdominal pain, generalized itching, dark urine and jaundice, although some people may notice signs, according to the previous source.
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The most common medications that cause dili
The recent study in toxicology reports identified several medications that are more likely to cause liver lesions.
- Paracetamol (acetaminophen), a common free sales analgesic
- Non -steroidal anti -inflammatory drugs (NSAIDs), which are often used to treat headaches, fever and chronic inflammatory disorders
- Aspirin, a common free sale medication used as a fever reducer, analgés
- Nimesulide, a NSAID used to relieve pain and reduce fever
- Metotrexate, an antimetabolite medication used to treat rheumatoid arthritis, lymphoma, leukemia and other types of cancer
- Corticosteroids, which are used to treat conditions that involve inflammation or hyperactive immune systems
- Isoniazid, a first -line treatment for tuberculosis
- Tetracyclines, a class of antibiotics that treat multiple types of bacterial infections
- Halotano, which is used as general anesthesia during surgical procedures
Turmeric, a common spice added to food, has been linked to the possible liver toxicity. (Istock)
Supplements linked to liver damage
Medications are not the only agents that can cause drug -induced liver lesions.
Dr. Marc Siegel, News senior medical analyst, spoke with News Digital about the risks of herbal and dietary supplements (HDS) that affect the liver.
“The biggest problem with herbal supplements is that the amount that is taking from active chemicals is not strictly regulated, so you don’t know exactly what you are getting.”
“The biggest problem with herbal supplements is that the amount that is taking active chemicals is not strictly regulated, so you don’t know exactly what you are getting,” he said.
“And since several of the supplements are metabolized through the liver, there is now a growing incidence of liver toxicity in users.”
Garcinia Cambogia, a popular weight loss supplement, is among the commonly used botanical products known for their possible liver toxicity. (Istock)
According to a study of 2024, published in Jama Network Open Open, Dili cases linked to herbal or dietary supplements have almost tripled between 2004 and 2014.
The researchers identified the following most used botanical products known for possible liver toxicity.
- Turmeric, a common spice added to food
- Green tea
- Ashwagandha, a herb used for stress and anxiety
- Garcinia Cambogia, a popular losing weight supplement
- Red yeast rice, which is said to help reduce cholesterol levels
- Black Cohosh, a dietary supplement used to relieve the symptoms of menopause
It is estimated that at least 15.6 million American adults have used at least one of these six botanical products in the last 30 days.
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“The most commonly involved botanical products in the dilin (Drug -induced hepatic lesions network) include turmeric, kratom, green tea extract and Garcinia Cambogia, with potentially serious and even fatal liver lesions,” said the study.
The hepatic lesion induced by drug caused by HDS can be serious or even fatal, which leads to death or liver transplant, the researchers pointed out.
Toxic hepatitis or hepatotoxicity, which is known to be a significant cause of acute liver failure, has been growing in Western countries since the 1960s. (Istock)
Siegel de News also warned of possible risks related to the liver of some of these appointed supplements.
“Turmeric is a natural anti -inflammatory and can be useful in small doses, but it can be toxic in large doses,” he warned.
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“Garcinia Cambogia is very popular, especially as a weight loss agent, but there is no real evidence that it really works, and there is no reason to carry it, especially with the new GLP-1 drugs.”
While red yeast rice has statin -type properties that reduce cholesterol, Siegel warned that the amount of active chemicals is not as strictly regulated as approved medications.
“Turmeric is a natural anti -inflammatory and can be useful in small doses, but it can be toxic in large doses.”
“It seems useful in some patients who are reluctant to start statins and are looking for a more natural alternative, but I must strictly monitor the amount taken and the effect on the liver,” he said.
With respect to green tea, Siegel said it has antioxidant properties and it can be useful to consume as a drink (although it has a lot of caffeine), “but there is no reason to take more in an extract, where it can be toxic.”
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The FDA establishes on its website that regulates the products of dietary supplements and dietary ingredients, but under “a different set of regulations than those that cover” conventional “” food and pharmaceutical products.
Heps -induced liver lesion caused by HDS can be serious or even fatal, which leads to death or liver transplant. (Istock)
“Manufacturers and distributors of dietary supplements and dietary ingredients are prohibited from marketing products that are adulterated or erroneous,” says the agency. “That means that these companies are responsible for evaluating the safety and labeling of their products before marketing to ensure that they meet all the requirements of the Federal Food, Medicines and Cosmetic Law amended by DSHEA and the FDA regulations.”
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News Digital contacted several researchers and the FDA regarding the increase in hepatic injury related to drugs and HSD.
Melissa Rudy is a senior health editor and a member of the lifestyle in News Digital. The advice of history can be sent to melissa.rudy@News.com.