Men face the risk of double dementia if they have a hidden genetic mutation

A hidden genetic mutation could predict a man’s probability of developing dementia.

That is according to an Australian study led by the universities of Monash and Curtin, which analyzed the medical data of thousands of Australians and American.

It was discovered that men who had a certain variant in the hemochromatosis (HFE) gene, which regulates iron levels in the body, had a higher risk of dementia, the researchers found.

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Previously, healthy men over 70 who have two copies of the variant, which is known as H63D, are at least twice, or up to four times, as a chance of developing dementia.

Having a single copy did not seem to raise the risk.

One in 36 men has two copies of the mutation; One in three has only one copy.

“Only men have two copies of the variant that are at risk,” said study professor, study professor, John Olynyk at the Curtin Faculty of Medicine, News Digital. “Women are not affected by abnormality: we don’t know why that is at the present time.”

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The study, which was published in the Neurology magazine, used aspirin data in reducing events in the elderly trial (ASPREE), which gathered health and aging data for 19,114 healthy older adults.

Those who have the genetic variant cannot change it, but it is possible that the “brain paths” that affects can be treated, said Olynyk.

“The HFE gene is routinely proved in most Western countries … when evaluating people for hemochromatosis, a disorder that makes the body absorb too much iron,” said the doctor. “Our findings suggest that perhaps this test could be offered to men more widely.”

Despite the fact that the HFE gene is responsible for controlling iron levels, the team did not find any direct link between the risk of iron and dementia.

“Our findings suggest that perhaps this test could be offered to men more widely.”

“This points to other mechanisms at stake, possibly involving the greatest risk of brain injury due to inflammation and cell damage in the body,” Olynyk added.

More research is needed to determine why the high risk was not observed in women.

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“Understanding why men with the double H63D variant have a higher risk could pave the way for more personalized approaches to prevention and treatment,” added the co -author Professor Paul Lacaze of the University of Monash in a press release.

The main limitation of the study, according to Olynyk, was that the study population was largely composed of Australians.

“If other populations exhibit the same effects, it is not clear,” he told News Digital. “Our work must be repeated in different countries to evaluate this.”

“More research will be carried out to try to determine the probable mechanism by which this anomaly causes dementia and what else can we do to reduce the impact of it.”

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Beyond this specific mutation, many other genetic and environmental factors can contribute to the risk of dementia, said Olynyk.

“While genetic risk factors cannot be changed, the mechanisms by which these genetic anomalies and environmental factors cause diseases can be modifiable to some extent, by adopting a healthy lifestyle and being proactive to maintain a good state of general health,” he said.

To reduce the risk, researchers recommend adopting a healthy lifestyle that includes exercising regularly, eating a nutritious diet, minimizing alcohol intake, remaining mentally active and seeing a doctor to address any medical problem that is known to increase the probability of dementia.

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The University of Melbourne, the Royal Children’s Hospital, the Murdoch Children’s Research Institute and the Fiona Stanley hospital also contributed to the study.