Oprah joins wave of celebrities revealing dramatic weight loss in 2025

Celebrities have been striving to be healthy in 2025 and many have lost significant amounts of weight, in many cases with the help of GLP-1 medications like Ozempic.

Below are four A-list stars who shared their weight loss journeys this year, with or without the help of prescription medications.

No. 1: Oprah Winfrey

Veteran talk show host Oprah Winfrey recently appeared in an exclusive interview with People magazine, during which she discussed her weight loss and her new book, “Enough: Your Health, Your Weight and What It’s Like to Be Free.”

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Winfrey, 71, started taking a GLP-1 drug in 2023, but tried to stop just six months later to see if she could lose weight without it. Regardless of her diet and exercise routines, the media mogul said she still gained 20 pounds after stopping the medication.

“It’s going to be something that will last a lifetime,” he shared. “I’m on high blood pressure medication, and if I stop, my blood pressure will go up. I realize the same thing is happening now with these medications. I’ve proven it to myself. [that] I need it.”

Winfrey revealed that her default weight, 211 pounds, was unhealthy, as she was prediabetic and had high cholesterol.

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The author told People that she injects GLP-1 weekly and that she also paid out of pocket for friends who couldn’t afford the medication.

Winfrey added that the absence of food noise “has given me a quiet strength that comes with everything I do. Everything is quieter and stronger.”

Regardless of access or tolerance to GLP-1, Winfrey encouraged those struggling with obesity to say “it’s not your fault.”

“I want people to stop blaming [themselves] for genes and the environment [they] “I can’t control,” he said. “I want people to have the information, regardless of what they choose to do with it, whether they take the medications or whether they want to continue dieting.”

No. 2: Amy Schumer

Comedian Amy Schumer lost 50 pounds after being diagnosed with Cushing’s syndrome, a hormonal disorder that can cause extreme bloating, fatigue and potentially fatal complications.

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Schumer’s transformation sparked an online conversation, to which she responded in a now-deleted Instagram post that ended speculation about cosmetic enhancements.

“I didn’t lose 30 pounds, I lost 50,” she emphasized on social media, adding that she doesn’t get Botox or fillers.

Schumer insisted that her weight loss was not about her looks, but about staying alive. He also confirmed that he has used the GLP-1 drug Mounjaro.

“Not looking sexy, which feels fun and temporary,” she said. “I did it to survive. I had a disease that makes your face extremely swollen and can kill you, but the Internet caught it and that disease disappeared.”

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“I’m sorry for any feelings I’ve given you that I’ve lost that weight,” he added. “I have had plastic surgery over the years and use [Mounjaro] …I have no pain. Can [play] tag with my son.”

The actress also addressed her hormonal changes, saying she is “happy to share more if anyone has any questions about how I look or feel or where I am in my perimenopause journey.”

No. 3: Meghan Trainor

“All About That Bass” singer Meghan Trainor also took on her haters for “body shaming” her after a dramatic 60-pound weight loss.

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Trainor recently told “Entertainment Tonight” that she has “never felt better” and is taking care of her health for the first time since having her two children.

“I feel very good and that’s when people attack me,” he said, noting that the criticism is increasingly “stronger” and “more cruel.” Despite the online noise, Trainor emphasized that she is focused on her well-being.

“I’m taking care of myself,” he reiterated. “I have to find a way to not be affected by it.”

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The singer’s health journey began by eliminating gluten and dairy from her diet after discovering she had a “leaky gut.” The artist also took strength training seriously.

Trainor’s own fitness trainer, Bella Maher of Malibu Bodies, posted before and after photos of the pop star on Instagram, revealing how hard she worked before introducing a GLP-1 medication.

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“Watching her transform from the inside out has been one of the most meaningful parts of my job,” the caption reads. “She did a lot of this on her own before introducing a GLP-1, and even after starting, the medication was simply a support, not the reason for her results. GLP-1s may be a powerful tool, but they are certainly not a transformational plan. SHE is the reason this worked.”

No. 4: Lizzo

The singer and musician Lizzo stood out this year with a slimmer figure, while the public speculated about her use of GLP-1.

During a discussion about Ozempic on Trisha Paytas’ “Just Trish” podcast in June, the musician shared that he had “tried everything” to lose weight.

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“Ozempic works because you eat less food,” he said. “It makes you feel full. So if you can do it on your own and put mind over matter, it’s the same thing.”

Lizzo shared that ending her vegan diet and eating more meat helped her maintain a calorie deficit, as she once consumed “a lot of fake meat,” bread, and rice.

“And I had to eat a lot to stay satisfied… I consumed between 3,000 and 5,000 calories a day.”

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“For me, when I started eating whole foods, like beef, chicken and fish, I was actually full and I didn’t expand my stomach by putting a lot of…fake things in there that didn’t really fill me up,” she added.

The Grammy winner revealed that her biggest inspiration for losing weight was relieving the intense back pain she felt after performing on stage.

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“My body hurt,” he said. “I want to be Tina Turner. I want to do stadium shows when I’m 70. If my back is on this track right now, there’s no way.”

News Digital’s Stephanie Giang-Paunon contributed to this report.