The genetic mutation of the sperm donor linked to cancer in 10 children conceived

According to reports, the sperm of a single donor in Europe have been used to conceive at least 67 pregnancies, although the donor carried a rare mutation that causes cancer.

The donor’s mutation has been related to cancer diagnoses in 10 of these children, according to a report by The Guardian.

The case was brought to light after two families contacted their fertility clinics separately after the cancer diagnoses of their children were linked to a rare genetic variant called TP53.

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A mutation in the TP53 gene causes li-phase syndrome, which increases the risk of developing cancer. Cleveland Clinic states that this disorder has a 90% probability of developing some type of cancer at 60 years and 50% possibilities of 40 years.

The European sperm bank, the sperm supplier, confirmed that this variant was present in some of the donor’s sperm.

The Guardian reported that the rare variant “was not known that it was linked to cancer at the time of donation in 2008”.

According to reports, the genetic variant would not have been detectable through standard detection, and it is said that the donor currently has good health.

“The identified mutation is one that could not have been detected by the detection methods we use according to the regulations.”

Dr. Edwige Kasper, a biologist at the Hospital of the University of Rouen in France, presented this case at the annual conference of the European Society of Human Genetics in Milan last week, commenting on the need for a European limit in the number of births or families for a single donor.

“We cannot make full genome sequencing for all sperm donors, I’m not arguing for that,” he told The Guardian. “But this is the abnormal diffusion of genetic disease. Not all men have 75 children throughout Europe.”

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Kasper analyzed the mutation in his laboratory, concluding that it was probably a cause of cancer and that children born to this donor should “receive genetic advice.”

The investigation turned into investigation tracked 67 children from 46 families in eight European countries. The children were evaluated, with the variant detected in 23 of them.

According to the reports, the 10 that had been diagnosed with cancer included cases of leukemia and non -Hodgkin lymphoma.

In a statement sent to News Digital, the European sperm bank stated that donor -assisted reproduction “generally remains a significantly more safer alternative” than reproduction without genetic detection.

The Bank added that sperm donors undergo a “comprehensive health exam”, which includes a deep medical examination, a review of the donor’s family medical history and “extensive” tests for genetic and infectious diseases.

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“However, it is not possible to rule out all the risks, and, in this particular case, the identified mutation is one that could not have been detected by the detection methods we use according to the regulations and would require specialized genetic evidence,” the group said.

Julie Paulli Budtz, vice president. of corporate communications in the European Bank of Sperm, expressed to News Digital that are “deeply affected by this case.”

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“The donor has been thoroughly tested even beyond the required standards, but preventive genetic detection is reaching its limits here,” he said.

“Each human being has about 20,000 genes, and scientifically it is not simply possible to detect mutations that cause diseases in a person’s gene group if he does not know what he is looking for.”

Budtz said the European sperm bank welcomes the “continuous dialogue” with respect to establishing an “internationally binding family limit”, which they have advocated “on several occasions, also at the EU level.”

“This is also the reason why, in addition to complying with the national limits of pregnancy, we have proactively implemented our own international limit of 75 families by donor,” he added.

What to know about US sperm donation guidelines.

In the US, there is no official legal limit on how many sperm donations a man can make.

However, the American Society of Reproductive Medicine (ASRM) recommends that donors be limited to 25 living births within each population area of ​​800,000 people.

“Institutions, clinics and sperm banks must maintain sufficient records to allow a limit to be established for the number of pregnancies for which a specific donor is responsible,” says the ASLM on its website.

“Limiting donor roads is an important part of the process.”

California Cryobank, who has claimed to have the highest selection of sperm and egg donations in the country, says on its website that donors closely monitors to limit the total number of family units to 20 to 30 worldwide.

“Limiting donor roads is an important part of the process,” said the bank.

The Federal Administration of Medicines of the United States (FDA) requires that all sperm donors undergo a physical examination, complete a questionnaire, provide their medical history and submit to exams of infectious diseases in a laboratory approved by the FDA.

In addition, the ASLM suggests that donors undergo psychological and genetic detection, and also recommends the infectious disease test of the recipient and sexually sexually intimate couples of the recipient, according to their website.

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“The consultation and legal laws may vary according to the State,” says the organization.

In California Cryobank, donors must be tested to detect infectious diseases, undergo genetic detection, obtain a psychological evaluation and a criminal history verification and receive the detection of the Zika virus, according to the bank’s website.